After starting my Manhattan-based dermatology practice over 20-years ago, I set forth to find a way to create an all-in-one, anti-aging skin care solution for my patients.

"My patients and the beauty editors who frequented my office told me they found it nearly impossible to keep up with the countless new ingredients on the market touted for daily skincare and were scared of the toxins to which they were being exposed.  

To have individual products that can do everything would cost thousands of dollars a month, not to mention the time and unwanted layers of toxic chemicals in a day-to-day routine. That’s why I started my skincare line."

Graduating from Harvard University with three degrees, BA, MD, and PhD, I became Double Board-Certified in Dermatology in the European Union as well as in the U.S. I also obtained a Fulbright in bioengineering and pioneered natural alternatives in agriculture. My scientific background and medical experience made me ideally suited to combining the healthiest plant-derived ingredients in formulating highly active skincare. Outside of my patient care endeavors, I have also served as a skincare expert for L’Oreal and Lancôme and Senior Editor for the Journal of Drugs in Dermatology, Editor of Dermatologic Surgery, JAMA Dermatology, Cosmetic Dermatology, Journal of Cosmetic and Laser Therapy, Journal of Laser Medicine and Surgery, and the Journal of the European Academy of Dermatology and Venereology, and am working on my 2500 page textbook, entitled, COSMETIC DERMATOLOGY. My academic and professional record of deeply-rooted research is what drives me to reach new heights in skincare.

I wanted to raise the bar in skincare both in plant-derived toxin-free actives and eco-conscious packaging as well as science. One of the exceptional things about my brainchild 37 Actives is that after the jar is opened it maintains 100% antioxidant activity up to six-months and its ‘actives’ up to three-years, while using mainly plant-based preservatives. No other brand goes to the lengths of post-market testing that 37 Actives has done. Our science is unprecedented.
With my experience as an attending physician at the Yale New Haven Hospital at Yale University and the West Haven VA Hospital at Yale University, and Lenox Hill Hospital and my lab-based skincare dermatology practice, I have a unique and solid knowledge of both medicine and the beauty industry. It is this knowledge that led me to create 37 Actives skin care collection, the only product line on the market that is: free of parabens, phthalates, plastics, sulfates, mica, talc, animal and human-derived ingredients, and propylene glycol; in recyclable glass and paperboard using USDA-certified organic plant-derived ingredients; with post-market testing showing full activity and stability out to three years; and 100% Made in USA with US-sourced ingredients. I hope you enjoy my brainchild and the passion of my life, 37 Actives. 
Kind regards,
Dr. Macrene Alexiades

For more information or to schedule an interview with Dr. Macrene, please reach out to: