Clinical Results

All 37 Actives products are rigorously tested by the most highly regarded third party testing laboratories.

37 Extreme Actives high performance anti-aging cream

Third-Party Clinical Laboratory Testing

A third party testing laboratory assessed 37 Extreme Actives in clinical trials, using objective tools designed to quantitatively measure changes in the multiple categories of cosmetic skin aging at 4, 6, and 8 weeks of daily use. The results demonstrated statistically significant decreases in the appearance of fine lines and wrinkles, the appearance of cosmetic blotches, and improvement in texture and skin tone using objective clinical measures by computer analysis. Not one case of irritation was observed, demonstrating excellent tolerability in all skin types.

Post-Manufacture Testing 

37 Actives is the first cream in the cosmetic realm to conduct post-market testing of the activity of the actives, shown to maintain 100% antioxidant activity to 6 months after jar opening and to maintain virtually all of actives at original levels up to 3 years post-manufacture (see below).

The actives in this highly advanced cream are the culmination of the very best scientific research from the lab, proven to also work on a clinical level, so that this one pot delivers results in all aspects of skin health, and systematically helps address the appearance of the many cosmetic changes of the skin over time.


Wrinkle Appearance Reduction

When measurements taken after 4, 6 and 8 weeks of product use were compared with baseline measurements, there was:

  • An 8.5% decrease (improvement) in the appearance of crow’s feet fine line / wrinkles after 4 weeks of product use;
  • A 17.0% decrease (improvement) in the appearance of crow’s feet fine line / wrinkles after 6 weeks of product use; and
  • A 17.0% decrease (improvement) in the appearance of crow’s feet fine line / wrinkles after 8 weeks of product use.

Appearance of Red Blotches Reduction

When measurements taken after 4, 6 and 8 weeks of product use were compared with baseline measurements, there was:
  • A 4.7% decrease (improvement) in the appearance of red blotchy skin after 4 weeks of product use;
  • A 6.4% decrease (improvement) in the appearance of red blotchy skin after 6 weeks of product use; and
  • A 10.9% decrease (improvement) in the appearance of red blotchy skin after 8 weeks of product use.

Appearance of Brown Blotches Reduction

When images taken after 4, 6 and 8 weeks of product use were compared with baseline images, there was:

  • A 1.1% improvement in brown blotchy skin after 4 weeks of product use;
  • A 2.1% improvement in brown blotchy skin after 6 weeks of product use; and
  • A 3.4% improvement in brown blotchy skin after 8 weeks of product use.

Laboratory Results

Antioxidant Activity



Extreme Active maintains 100% antioxidant activity 6 months after you open your jar.  100% of the actives are maintained at original levels out to 2 years.  



Competitors lose 50% of their antioxidant capability at 6 months and some creams have no actives, only preservative left at 1 year.


Safety

A third party laboratory tested the product for safety, showing not a single irritation reaction in any patient across the 35 subject study.

Competitors lose 50% of their antioxidant capability at 6 months and some creams have no actives, only preservative left at 1 year.

 


Published Clinical Trials

37 Extreme Actives was tested in an institutional review board approved clinical trial and published in the Journal of Drugs in Dermatology. 

Baseline (Left) and 1 Month (Right) Follow-Up Clinical Photographs Following Application of 37 Extreme Actives high performance anti-aging cream and Impact.

 

 

 

37 Actives Neck and Décolletage Anti-Aging Treatment Lotion

Third-Party Clinical Laboratory Testing

A third party testing laboratory assessed 37 Actives in clinical and consumer studies, using objective tools designed to quantitatively measure changes in the multiple categories of cosmetic skin aging. The results demonstrated statistically significant improvements in the appearance of fine lines and wrinkles, brown discolorations, and radiance of the skin of the neck and chest at 4, 8 and 12 weeks. 

Proven Claims

A patented anti-aging treatment that incorporates intelligent skin design by using 37 cosmetically relevant ingredients that address the multiple signs of aging in one bottle.  The anti-aging ingredients are selected based upon the efficacy within each anti-aging ingredient category and encased in individual liposomes for targeted delivery to the skin

Contains a collection of anti-aging peptides, hyaluronic acid, amino acids, fatty acids and skin boosters

Contains vitamins C & E, resveratrol and extracts of red algae, pomegranate, mushroom, bark, coffee, green and yerba mate tea, watermelon, among other plant actives

Helps hydrate and moisturize with emollients, including sodium lactate, squalane, glycerin, soy lecithin, fatty acids and hyaluronic acid

The neck & décolletage lotion is filled in a glass bottle, is paraben free, propylene glycol free, fragrance free, phthalate free, sulfate free and free of animal or human derived ingredients

In a third-party clinical study, there was a highly statistically significant improvement in the appearance of wrinkles and fine lines of the neck and chest of 2.37% by 8 weeks and 5.62% by 12 weeks.

4 week proven claims:

In a consumer survey after 4 weeks, 100% of subjects reported that the product helped soothe the skin and left their skin feeling comfortable

In a consumer survey after 4 weeks, 100% of subjects reported that the product absorbs well into the skin with a good texture and ease of application

In a consumer survey after 4 weeks, 96.77% of subjects agreed they liked the scent level of the product and 93.55% of subjects agreed they liked the way it smells

In a consumer survey after 4 weeks, 93.55% of subjects agreed that their skin felt softer after using the product, 83.87% of subjects agreed the softness of their skin on their neck and chest had improved and 79.03% of subjects agreed the texture of the skin on their neck and chest had improved

In a consumer survey after 4 weeks, 83.87% of subjects agreed the product to be one of the best neck and décolletage lotions that they ever used, would recommend it to a friend or family member and would continue to use it.

80.65% of subjects reported that their fine lines and wrinkles are visibly improved after using 37 Actives.

In a consumer survey, 80.65% of subjects agreed that the product improved the way they feel about their skin after 4 weeks and after 12 weeks, 75.81% of subjects agreed that their results kept getting better after each week of use.

In a third-party clinical study, 80.65% of subjects reported that their neck and chest feels firmer;

87.10% of subjects reported improvement in the smoothness of the skin on the neck and chest.

In a third-party clinical study, 90.32% of subjects reported the skin on the neck and chest felt more hydrated and moisturized instantly after application.

83.87% of subjects reported that their skin looks brighter and more radiant after using 37 Actives.

8 week proven claims:

In a study, there was an improvement in the appearance of wrinkles and fine lines of the neck and chest in 8 weeks and 12 weeks. 

80.65% of subjects reported that their fine lines and wrinkles are visibly improved after using 37 Actives.

In a third-party clinical study, 79.03% of subjects reported improvement in the texture of the skin on the neck and chest.

In a third-party clinical study, 74.19% of subjects reported the skin on the neck and chest had less of a red or ruddy appearance.

77.42% of subjects reported that their skin tone looks more even after using 37 Actives.

74.19% of subjects reported that 37 Actives energizes their complexion each day.

74.19% of subjects were amazed at how great their skin looks after using 37 Actives.

80.65% of subjects reported that their skin looks younger after using 37 Actives.

80.65% of subjects reported that their neck feels firmer.

80.65% of subjects reported that their chest feels firmer.

12 week proven claims:

In a study, there was an improvement in the appearance of wrinkles and fine lines of the neck and chest in 8 weeks and 12 weeks

In a consumer survey, 87.10% of subjects agreed the smoothness of the skin on the neck and chest appeared improved and 80.65% of subjects agreed the appearance of their fine lines and wrinkles were visibly improved after using the product for 12 weeks

In a consumer survey, 87.10% of subjects agreed the skin on their neck and chest looked smoother after using the product for 12 weeks

In a consumer survey, 80.65% of subjects agreed that their skin looked more radiant, revitalized and refreshed after using the product for 12 weeks

In a consumer survey, 93.55% of subjects agreed that their skin felt softer and after 12 weeks, 90.32% of subjects agreed the skin on their neck and chest felt more hydrated and moisturized instantly after application of the product.

In a consumer survey, 83.87% of subjects agreed that their neck and chest skin looked healthier and 85.48% of subjects agreed the appearance of the overall quality of the skin on their neck and chest had improved after using the product for 12 weeks

In a consumer survey, 80.65% of subjects agreed that the product improved the way they feel about their skin after 4 weeks and after 12 weeks, 75.81% of subjects agreed that their results kept getting better after each week of use

In a study, according to an expert grader, the product helped improve the appearance of skin tone after 12 weeks.

In a third-party clinical study, 83.87% of subjects reported 37 Actives neck and décolletage treatment to be one of the best neck and décolletage lotions that they ever used, would recommend it to a friend or family member, and would continue to use it.

79.03% of subjects reported that they prefer 37 Actives neck and décolletage treatment over any other anti-aging neck and décolletage treatment they’ve tried before.

75.81% of subjects reported that their results keep getting better and better after each week of use.

 

 37 ACTIVES high performance anti-aging treatment foundation

Third-Party Clinical Laboratory Testing

A third party testing laboratory assessed 37 Actives in clinical and consumer studies, using objective tools designed to quantitatively measure changes in the multiple categories of cosmetic skin aging. The results demonstrated statistically significant improvements in the appearance of fine lines and wrinkles, brown discolorations, and radiance of the skin of the face at 4, 8 and 12 weeks. 

PRODUCT BENEFITS (CLINICALS)

Dr. Macrene’s 37 Actives Treatment Foundation is a patented anti-aging cream that incorporates intelligent skin design by using over 30 cosmetically essential ingredients that address the multiple signs of aging in a buildable coverage foundation.

The anti-aging ingredients are selected based upon the efficacy within each anti-aging ingredient category

37 Actives Treatment Foundation contains a collection of anti-aging peptides, hyaluronic acid, amino acids, fatty acids, minerals and skin boosters that help to reduce the appearance of fine lines and wrinkles

37 Actives contains vitamins C & E, ferulic acid, resveratrol, bisabolol, and extracts of plankton, algae, mushroom, bark, coffee, green tea, pomegranate, feverfew, gingko, camellia sinensis among other plant actives, and superoxide dismutase, which are antioxidants that help fight free radical attack from sun exposure and pollutants.

In this product, cosmetically essential ingredients are encased in individual liposomes for targeted delivery to the skin

High quality emollients are used to help keep the skin hydrated, including glycerin, soy, and small size hyaluronic acid molecules are used to help with skin penetration

The product is paraben free, propylene glycol free, fragrance free, phthalate-free, sulfate-free, talc-free, mica-free, acne free, free of animal or human derived ingredients and no animal testing. It is non-acnegenic.

37 Actives, which contains jojoba esters, squalane, dimethicone and sunflower and sandalwood extracts, helps provide moisturization to the skin 

In a third-party clinical study, 93.94% of subjects demonstrated an improvement in the appearance of hyperpigmentation and age spots following application of 37 Actives Treatment Foundation

In a third-party clinical study, there was a 12.04% improvement in the appearance of hyperpigmentation and age spots following application of 37 Actives Treatment Foundation

In a third-party clinical study, there was a 5.79% improvement in the appearance of global fine lines and wrinkles following application of 37 Actives Treatment Foundation

In a third-party clinical study, there was a 4.16% improvement in the appearance of global fine lines and wrinkles as compared to baseline following 12 weeks of product use but prior to re-application of 37 Actives Treatment Foundation 

In a third-party clinical study, there was a 2.59% improvement in the appearance of hyperpigmentation and age spots as compared to baseline following 12 weeks of product use but prior to re-application of 37 Actives Treatment Foundation

The following clinical results were statistically significant:

96.97% of subjects reported that they liked the way the product smells

96.97% of subjects reported that 37 Actives absorbs well into the skin

78.79% of subjects reported that their skin looks smoother

75.76% of subjects reported that their skin tone looks more even

90.91% of subjects reported that their skin feels softer

96.97% of subjects reported that they like the way the foundation blends into the skin

93.94% of subjects reported that 37 Actives Treatment Foundation feels good on the skin

87.88% of subjects reported that the 37 Actives Treatment Foundation makes their skin feel moisturized and refreshed

 ***100% of subjects reported that their skin looks natural after using 37 Actives Treatment Foundation

 ***96.97% of subjects reported that 37 Actives Treatment Foundation blends in well with their skin color

 *100% of subjects reported that when they use 37 Actives Treatment Foundation, it does not look like their wearing foundation

 81.82% of subjects reported that after this clinical study, they would continue to use 37 Actives Treatment Foundation

81.82% of subjects reported that they would recommend 37 Actives Treatment Foundation to a friend or family member

 78.79% of subjects reported that 37 Actives Treatment Foundation is one of the best foundations that they have ever used

93.94% of subjects reported that 37 Actives Treatment Foundation had excellent texture 

96.97% of subjects reported that 37 Actives Treatment Foundation had ease of application

93.94% of subjects reported that 37 Actives Treatment Foundation left the skin feeling comfortable

90.91% of subjects reported that 37 Actives Treatment Foundation soothed the skin

87.88% of subjects reported that they liked the scent level of 37 Actives Treatment Foundation

100% of subjects reported that 37 Actives Treatment Foundation absorbs well into the skin

90.91% of subjects reported that their skin looks brighter and more radiant

87.88% of subjects reported that their skin looks healthier

84.85% of subjects reported that their skin looks revitalized and refreshed

87.88% of subjects reported that their skin tone looks more even after having used 37 Actives Treatment Foundation

 90.91% of subjects reported that their skin feels calmed after having used 37 Actives Treatment Foundation

81.82% of subjects reported that 37 Actives Treatment Foundation improves the way they feel about the skin

78.79% of subjects reported being amazed at how great their skin looks after having used 37 Actives Treatment Foundation

81.82% of subjects reported seeing a minimization of pores

93.94% of subjects reported liking the way the foundation blends into the skin

93.94% of subjects reported that the product feels very good on the skin

87.88% of subjects reported that the foundation makes their skin feel moisturized and refreshed

**90.91% of subjects reported that their skin looks natural after using 37 Actives Treatment Foundation

 **90.91% of subjects reported that 37 Actives Treatment Foundation blends well with their skin color

84.85% of subjects reported that 37 Actives Treatment Foundation covers blemishes

 **93.94% of subjects reported that 37 Actives Treatment Foundation did not make their skin breakout!

*75.76% of subjects reported that their skin feels healthier

93.94% of subjects reported that they do not need to reapply 37 Actives Treatment Foundation throughout the day – it does not melt and wears all day!

90.91% of subjects reported that when they use 37 Actives it does not look like they are wearing foundation

84.85% of subjects reported that after the clinical study, they would continue to use the product

87.88% of subjects reported that after the clinical study, they would recommend this product to a friend or family member