37 Extreme Actives Anti-Aging

Updated formula now contains 50 anti-aging ingredients, addresses all your anti-aging needs:

Anti-Wrinkle: Build skin thickness with clinically proven reduction in appearance of wrinkles 4,6 

Palmitoyl Oligopeptide – peptide proven to reduce wrinkles
Palmitoyl Tetrapeptide-7 - peptide proven to reduce wrinkles
Sodium Hyaluronate – the lowest molecular size available – gets INTO your skin like no otherHordeum Distichon (Barley) Extract - natural source of EGF, growth factor
Resveratrol
Tetrahexyldecyl Ascorbate
Plankton and Blue Algae Extract (Photosomes)
Tremella fuciformis (mushroom) polysaccharide
Hordeum Distichon (Barley) Extract natural source of EGF

Anti-Oxidants: Powerful protection against UV damage 7 

Ferulic Acid – the best UVA protection around – in Skinceuticals CEFerulic
Resveratrol – from red wine and red grapes – powerful antioxidant
Tetrahexyldecyl Ascorbate – most stable vitamin C available
Tocopherol – always need Vitamin E to complete your anti-oxidant mix
Magnesium ascorbyl phosphate and tocopherol (Oxysomes) – double duty C & E combo in liposomes
Ilex paraguariensis (yerba mate) leaf extract - organic – unique to 37EA Brazilian secret to anti-oxidant
Plankton and Blue Algae Extract (Photosomes)
Helianthus annus (sunflower) extract
Santalum album (sandalwood) extract
Phellodendron amurense (bark) extract 
Hordeum distichon (barley) extract
Coffea arabica (coffee) seed extract - organic
Theobroma cacao (cocoa) extract
Ilex paraguariensis (yerba mate) leaf extract

Anti-Pigment: Lighten brown blotches 3,4 

Glucosamine – hot new anti-pigment ingredient found in Clinique Spot Corrector and Olay ProX
Arginine – used by Dr Macrene in brightening peels by NeoStrata
Ergothioneine – licensed gentle amino acid derivative anti-pigment
Aspartic Acid
Glycine
Alanine
Serine
Valine
Proline
Threonine
Isoleucine
Histidine
Phenylalanine
Soy
Acetyl-Tyrosine
Plankton and Blue Algae Extract (Photosomes)

Anti-Red: Outstanding reduction in redness and inflammation 4,5 

Bisabolol – the active ingredient in Chamomile
Coffea arabica (Coffee) seed extract –organic – the active in Revale which is outstanding at redness-reduction
Caffeine – constricts broken capillaries and depuffs!
Chrysanthemum parthenium (Feverfew) extract- organic – soothing inflammation
Ilex paraguariensis (Yerba mate tea) leaf extract - organic – unique to 37EA, this is a powerful anti-anti-ager is a well known weapon used in Brazil
Theobroma cacao (Cocoa) extract - organic
Soy

DNA repair: Help correct the damage to your DNA that causes skin aging 1 

Plankton and Blue Algae Extract (Photosomes) – cutting edge sea derived repair ingredients
Micrococcus Extract (Ultrasomes) – anti-aging DNA repair enzymes with excellent scientific proof
Arabidopsis thaliana extract (Roxisomes) – outstanding cell & DNA repair proven on molecular level
Hydrolyzed Vegetable Protein (delivery)
Resveratrol
Magnesium ascorbyl phosphate and tocopherol (Oxysomes)

Cellular Restore: General clean-up of daily toxic exposure 2 

Resveratrol – the housekeeper of the cell
Soy – well-rounded anti-aging plant extract that cleans up cellular toxicity
Ferulic Acid
Magnesium ascorbyl phosphate and tocopherol (Oxysomes)
Arginine
Aspartic Acid
Glycine
Alanine
Serine
Valine
Proline
Threonine
Isoleucine
Histidine
Phenylalanine

Pro-Collagen: Stimulate skin thickness 8,9 

Palmitoyl Oligopeptide (and) Palmitoyl Tetrapeptide-7 – fragments of collagen that stimulate collagen genes (give signal to make more)
Tetrahexyldecyl Ascorbate – cofactor of enzyme that makes collagen
Magnesium Ascorbyl Phosphate -cofactor of enzyme that makes collagen
Sodium hyaluronate – shown to get into skin and serve to stimulate your own collagen
Hordeum Distichon (Barley) Extract natural source of EGF
Tetrahexyldecyl Ascorbate
Magnesium Ascorbyl Phosphate
Sodium hyaluronate

Barrier Repair: Therapeutically protect the skin 10 

Dimethicone – proven to last 24 hours and used for epidermal repair
Squalane - building block of outermost protective layer of skin
Santalum album (sandalwood) extract – studies proving barrier repair properties
Helianthus annus (sunflower) extract – studies proving barrier repair properties
Soy Lecithin – long history of use by Asians to repair skin barrier
Glycerin – excellent and well proven barrier repair
Sodium Lactate
Sodium PCA
Sodium hyaluronate
Magnesium ascorbyl phosphate
Trumella fuciformis polysaccharide
Simmondsia Chinensis (Jojoba) Butter
Hordeum distichon (Barley) Extract
Phellodendron amurense (Bark) Extract
Theobroma cacao (Cocoa) Seed Butter

Aging Reversal: Help reverse the signs of aging

Tremella fuciformis (mushroom) polysaccharide – mushroom shown to be powerful anti-ager
Resveratrol – lengthens lifespan in many studies
Phellodendron amurense (Bark) Extract – source of phloretin – powerful anti-ager
Ilex paraguariensis (yerba mate) leaf extract – the most powerful anti-ager on earth only in 37 EA
Palmitoyl Oligopeptide
Palmitoyl Tetrapeptide-7
Resveratrol
Ferulic Acid
Sodium hyaluronate
Hordeum Distichon (Barley) Extract natural source of EGF

Emollient/Moisturizers: Hydrate and maintain moisture in the skin 11 

Sodium Lactate – draws water molecules into the skin while exfoliating dead cells
Dimethicone – 24 hour emolliency
Glycerin – outstanding emollient
Soy Lecithin – long history of use by Asians as emollient
Cocoa extract - organic
Jojoba extract
Trimethylolpropane tricaprylate/tricaprate
Helianthus annus (sunflower) extract
Santalum album (sandalwood) extract
Hordeum distichon (barley) extract
Sodium hyaluronate
Sodium PCA
Squalane

Re-texturize: Reverse irregularities to skin texture with natural actives12 

Theobroma cacao (cocoa) extract - organic – natural anti-aging activities preventing abnormal cell growth, improves texture
Tremella fuciformis polysaccharide (mushroom extract) - normalizes growth of cells, improves texture
Resveratrol – regulates the cell cycle
Ferulic acid
Phillodendron amurense (bark) extract
Coffea arabica (coffee) seed extract - organic
Ilex paraguariensis (yerba mate) leaf extract - organic

References:
1. Schweikert K, McGregor W, Klein C, Dell'Acqua G. Amino acids to increase DNA repair after UVB irradiation of reconsituted human skin. SOFW Journal 2006; Vol 132, 22-28.
2. Gatz SA, Wiesmuller L. Take a break-resveratrol in action on DNA. Carcinogenesis 2008 Feb; 29 (2): 321-32.
3. Draelos Z. Skin lightening preparations and the hydroquinone controversy. Dermatol Ther 2007 Sept-Oct 20 (5): 308-13.
4. Alexiades-Armenakas M.R. The science behind 37 Extreme Actives. Clinical Trial Results, Essex Testing Laboratories, 2009; epub (www.drmacrene.com/ingredients of 37/science behind 37.
5. Thronfeldt CR. Incorporating natural therapy for rosacea. Practical Dermatol 2008 Nov; 38-43.
6. Fisher GJ, Varani J, Voorhees JJ. Looking older: fibroblast collapse and therapeutic implications. Arch Dermatol 2008 May; 144 (5): 666-72.
7. Murray JC, Burch JA, Streilein RD, Iannacchione MA, Hall RP, Pinnell SR. A topical antioxidant solution containing vitamins C and E stabilitzed by ferulica acid provides protection for human skin against damage caused by ultraviolet irradiation. J Am Acad Dermatol 2008 Sep; 59 (3): 418-25.
8. Huang L, Gu H, Burd A. A reappraisal of the biological effects of hyaluronan on human dermal fibroblast. J Biomed Mater Res A. 2009 Sep 15: 90 (4): 1177-85.
9. Gessin JC, Gordon JS, Berg RA. Regulation of collagen synthesis in human dermal fibroblasts by the sodium and magnesium salts of ascorbyl-2-phosphate. Skin Pharmacol 1993; 6(1): 65-71.
10. Draelos ZD. Active agents in common skin care products. Plast Reconstr Surg 2010 Feb; 125 (2): 719-24.
11. Loden M. The clinical benefit of moisturizers. J Eur Acad Dermatol Venereol 2005 Nov; 19 (6): 672-88.
12. Liu EH, Qi LW, Wu Q, Peng YB, Li P. Anticancer agents derived from natural products. Mini Rev Med Chem 2009 Nov 1;9 (13): 1547-55.